The Illumina BeadArray Reader, p/n 11182022, is a laboratory microarray DNA analyzer that uses silica microbeads. On the surface of each array, or BeadChip, hundreds of thousands to millions of genotypes for a single individual can be assayed at once. These tiny silica beads are housed in carefully etched microwells and coated with multiple copies of an oligonucleotide probe targeting a specific locus in the genome.
As DNA fragments pass over the BeadChip, each probe binds to a complementary sequence in the sample DNA, stopping one base before the locus of interest. Allele specificity is conferred by a single base extension that incorporates one of four labeled nucleotides. When excited by a laser, the nucleotide label emits a signal. The intensity of that signal conveys information about the allelic ratio at that locus.
Trusted data quality and exceptional coverage of valuable genomic regions make our Infinium genotyping arrays the platform of choice by leading institutions for high-throughput screening and large-scale research programs. Infinium technology produces exceptional data quality and call rates, as well as consistent reproducibility. We offer a broad range of microarray options based on SNP complexity and sample throughput.