The Tissue-Tek Accu-Cut Rotary Microtome Type 4571 ensures secure, precise positioning of specimen block with universal cassette and orientation clamps while facilitating exact, rapid trimming via a trimming lever. Micron thickness is handled by an adjustable visual display to ensure accuracy. A universal blade holder base, featuring lateral displacement, allows operators to use the full length of the microtome blade without releasing the blade clamping mechanism or direct blade manipulation.