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Category: HPLC, UPLC, & LC/MS | Subcategory: LC-MS / LC-MS/MS | Manufacturer: Waters
Waters Xevo G2 QTof Quadrupole Time-of-Flight Mass Spectrometer With Acquity UPLC System
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The Waters Xevo G2 QTof Quadrupole Time-of-Flight Mass Spectrometer With Acquity UPLC System including model 186015006 Sample Manager, model 186015030 Photo Diode Array Detector, model 186015001 Binary Solvent Manager, model HTCH Degasser, & Solvent Tray is one of the most sensitive, exact-mass, quantitative and qualitative benchtop mass spectrometry systems available.
Xevo G2:
The Waters Xevo G2 QTof Quadrupole Time-of-Flight Mass Spectrometer With Acquity UPLC System features Intellistart Technology and Z-Spray ESI LockSpray Ion Source is made for the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples.
The Xevo G2 delivers not only conventional MS and MS/MS methots of data acquisition, it also has the ability to perform UPLC/MS to collect the maximum amount of data from a single analysis. UPLC/MS datasets provide a comprehensive digital record of your sample. The system incorporates IntelliStart Technology, for automated system optimization and status monitoring, ensuring that the highest quality data is routinely available to all levels of operator.
The Xevo G2 is equipped with a high resolution, high stability quadrupole analyzer (MS1), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers. The instrument is also equipped with a high performance oaTof mass analyzer (MS2) with a mass range up to m/z 100,000 and a resolving power of > 22,500 FWHM.
| Specifications | Xevo G2: |
| Dimensions | 27″ W x 34.4″ D x 59.8″ H (68.7 x 87.3 x 152 cm) |
| Regulatory Approvals | CE and NRTL |
| TOF Mass Range | m/z 20 to 100,000 |
| Quadrupole mass range, non resolving mode | m/z 20 to 16,000 |
| Quadrupole mass range, resolving mode | m/z 20 to 4,000 |
| Data acquisition rate | Up to 30 spectra per second |
| Mass measurement accuracy | Better than 1 ppm RMS |
| Mass resolution | > 22,500 FWHM |
| Power | 200-240 V, 50-60 Hz, 1.1 kW |
| Acquity System Power | 100-240 V, 50-60 Hz |
ACQUITY UPLC System
UPLC Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is highly robust, dependable, and reproducible.
- Work at higher efficiencies with a much wider range of linear velocities, flow rates, and backpressures
- Higher flow rates and increased throughput result in superior resolution and sensitivity
- Eliminate significant time and cost per sample, while improving quality of results
- Benefit from Waters’ patented sub-2-μm hybrid particle chemistry.
The ACQUITY UPLC System eliminates significant time and cost per sample from your analytical process while improving the quality of your results. By outperforming traditional or optimized HPLC, this technology allows chromatographers to work at higher efficiencies with a much wider range of linear velocities, flow rates, and backpressures.
UPLC Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is highly robust, dependable, and reproducible. What differentiates the holistic design of ACQUITY UPLC systems is Waters’ patented sub-2-μm hybrid particle chemistry, which offers significant benefits over today’s HPLC systems equipped with standard 5-μm particle chemistries.
The ACQUITY UPLC System, used on its own or paired with Waters optical and MS detection technologies, provides unique end-to-end solutions for all industries and applications, including: ADME screening, food safety, bioanalysis, clinical, metabolite identification, metabonomics, method development, opens access, and routine quality screens. Since its invention, ACQUITY UPLC Technology has enabled analytical chemists to reach far beyond conventional HPLC separations.
Features of the ACQUITY UPLC System:
- Comprehensive system components, including the ACQUITY UPLC Sample Organizer, Column Manager and Heater/Cooler, Binary Solvent Manager and Sample Manager, for customized throughput and condition requirements
- Easy HPLC to UPLC method conversion with the ACQUITY UPLC console calculator
- Support for existing HPLC methods
- Predictive system support with Connections INSIGHT® remote intelligent services
- Chemistries and formats to suit specific analytical tasks, including ACQUITY UPLC 1.7 μm columns, VanGuard pre-columns or ACQUITY UPLC HSS and HSS T3 1.8 μm columns
- Extended detection capabilities with ACQUITY UPLC Fluorescence (FLR), Tunable UV (TUV), Photodiode Array (PDA), Evaporative Light Scattering (ELS), and Refractive Index (RI) detectors to single, tandem, and time-of-flight mass spectrometers
- Easily compatible with third-party MS solutions (ABI/MDS SCIEX, Bruker Daltonics, and Thermo Fisher Scientific)
| Specifications | PDA Detector: |
| Wavelength Range | 190 to 800 nm |
| Light Source | Intelligent Technology Deuterium Lamp |
| Wavelength Accuracy | ±1 nm |
| Linearity Range | Deviation at 2.0 AU ≤5%, propylparaben, at 257nm |
| Optical Resolution | 1.2nm |
| Digital Resolution | 1.2 nm/pixel |
| Baseline Noise | ± µAU, 230 nm, 2 Hz, 2 s, wavelength compensation 310 to 410, WET (2D channel) |
| Drift | ≤1.0 x 10-3/AU/hour/°C |
| Flow Cell Design | Light-guiding UPLC intelligent technology flow cell |
| Pathlength | 10 mm (analytical cell) |
| Cell Volume | 500 nL (analytical cell) |
| Wetted Materials | 316 stainless steel, fused silica, Teflon AF, PEEK |
| Data Acquisition | Up to 80 Hz |
| Pressure Limit | 1000 psi |
| Unattended Operation | Leak sensors, full diagnostic data captured through console software |
| Dimensions | 13.5″ W x 23.9″ D x 7.6″ H (34.3 x 60.7 x 19.4 cm) |
| Weight | 30 lbs. (13.6 kg) |
| Operating Temperature | 4 – 40°C (39 – 104 °F) |
| Operating Humidity | 20% to <90% RH non-condensing |
| Compliance | CE Mark CSA C-tick and UL |
| Power | 100 – 240 VAC, 50/60 Hzx, 185 VA (nominal) |
| Specifications | Binary Solvent Manager: |
| Number of Solvents | Up to four, in combination of two, A1 or A2 and B1 or B2 |
| Solvent Conditioning | Integrated vacuum degassing, six lines with two allocated for the injector needlewash/purge solvents |
| Gradient Formation | High pressure mixing, binary gradient |
| Gradient Profiles | 11 gradient curves [including linear, step (2), concave (4), and convex (4)] |
| Primary Check Valves | Intelligent Intake Valves |
| Flow Accuracy | ±1.0% of set flow rate at 0.500 mL/min as per Systems QT |
| Flow Precision | 0.075% RSD or 0.01 min SD, (0.2 to 2.0 mL/min), whichever is greater using premixed solvent |
| Composition Ripple (baseline noise) | <1.0 mAu |
| Pump Compositional Precision | <0.15% RSD or 0.02 min SD, whichever is greater |
| Pump Compositional Accuracy | ±0.5% absolute from 5 to 95%, 0.2 to 2.0 mL/min |
| Compressibility Compensation | Automatic, no user intervention required |
| Priming | Wet priming runs at a flow rate of 4 mL/min |
| Pump Seal Wash | Equipped with a programmable active wash system to flush the rear of the high pressure seals and the plungers |
| Flow Ramping | Automatic |
| Primary Wetted Materials | 316L stainless steel, UHMWPE blend, MP35N, titanium alloy, gold, sapphire, ruby, zirconia, Nitronic 60, DLC, fluoropolymer PEEK, and PEEK blend |
| Mixing Options | 50 uL standard; 100 uL and 380 uL optional |
| Specifications | Sample Manager: |
| Number of Sample Plates | Two |
| Maximum Sample Capacity | 768 in two 384-well plates* |
| Number of Sample Injections | 1 to 99 injections per sample |
| Injection Volume Range | 0.1 to 50.0 iJL, in 0.1 iJL increments, partial or full loop mode; 10ul loop is standard |
| Sample Delivery Precision(Full Loop Injection Mode) | <0.3% RSO, full loop, standard lO-iJL loop (default wash/purge conditions), per Waters AQT/SystemsQT protocol |
| Sample Delivery Precision(PLNO Injection Mode) | <1% RSO within 20% to 75% of loop volume for 1, 2, 5, 10, 20, and 50-iJL loops, UV detection |
| Injector Linearity | >0.999 coefficient of deviation (from 20% to 75%, partial loop overfill mode (PLNO injection mode), per Waters’ AQT/SystemsQT protocol |
| Sample Temperature Control | 0 to 40.0 ·C, settable in 0.1 ·C increments (assumes an ambient temperature of 25.0 ·C)** |
| Injection Cycle Time | <15 sec between multipe injections with “load ahead” enabled; 30 sec with single weak wash, lO-iJL loop, pressure assist mode |
| Sample Probe | XYZZ based needle-in-needle design |
| Minimum Sample Required | 5 uL residual, using maximum recovery 2-mL vials (zero offset) |
| Wash Solvents | Two degassed: strong solvent and weak wash solvent, programmable to suit application |
| Sample Carryover | <0.005% or <2.000 nL, whichever is greater |
| Advanced Operations | Loop off-line mode, load ahead |
| Unattended Operation | Leak sensors, full diagnostic data control captured through console software |
| Primary Wetted Material | Titanium alloy, 316 stainless steel, fluoropolymer, fluoroelastomer, PPS alloy, PEEK alloy, PPS, PEEK, OLC coating, gold |
*expandable to up to 8,448 samples with optional Sample Organizer
**At an ambient temperature of 21.0 ·C or lower the sample manager will maintain the temperature of the sample compartment down to 4.0 ·C with a tolerance of -2.0/+6.0 ·C, when configured with the maximum number of vials and/or plates
Please note: system includes vacuum pump.
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