Category: Microplate Readers | Subcategory: Microplate

Wyatt Technology Dynapro Plate Reader III

Wyatt Technology Dynapro Plate Reader III Image

ITEM: 32287

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Wyatt Technology Dynapro Plate Reader III ImageWyatt Technology Dynapro Plate Reader III ImageWyatt Technology Dynapro Plate Reader III ImageWyatt Technology Dynapro Plate Reader III ImageWyatt Technology Dynapro Plate Reader III Image

The Wyatt Technology Dynapro Plate Reader III is designed for high-throughput sizing and screening of pharmaceutical and nanoparticle formulations to enable novel workflows that simply would not be possible with other DLS instruments. 

For biotherapeutic development, the Wyatt Technology Dynapro Plate Reader III is a comprehensive solution for stability evaluation. Measure aggregation, aggregate size distributions, changes in solution molecular weight, and propensity for aggregation. Indicators of both thermal stability and colloidal stability may be quantified with plate-based DLS and SLS. Even viscosity of concentrated protein solutions can be screened across dozens of formulations in a single plate.

For nanoparticle formulation and process development, including viral vectors, non-viral vectors and nano-drug delivery vehicles, the Wyatt Technology Dynapro Plate Reader III adds particle concentration / physical titer to basic DLS measurements of size and polydispersity. Its automation is particularly valued to screen fractions during process development and then to quantify CQAs in quality control.

Specifications: 

Supported Well Plate Formats: 96, 384 or 1536 
Dynamic Light Scattering
   -Size Range (Radius, Rh): 0.5 to 1000 nm
   -Minimum Concentration @ 14 kDa: 0.125 mg/mL 
Static Light Scattering
   -Molar Mass Range: 1000 to 1,000,000 Da
   -Minimum Concentration @ 67 kDa: 1 mg/mL 
Optics
   -Laser Wavelength: 830 nm
   -Laser Power Control Programmable: 10% – 100%
   -Attenuation Range: 1 to 105
Temperature Control: 4 to 85°C 
Fluidics
   -Minimum Sample Volume: 4 µL 
Data Acquisition Time: 1 to 3600 seconds per well per read
Read Time per Well: 5 – 20 seconds
Software: Dynamics

 

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