HPLC, UPLC, & LC/MS

High-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (UPLC), and liquid chromatography-mass spectrometry (LC/MS) systems are essential tools in modern analytical laboratories. These sophisticated instruments are used to separate, identify, and quantify the components within complex mixtures. They work by leveraging the principles of chromatography, where a sample is dissolved in a mobile phase and passed through a stationary phase (typically a packed column). The interaction between the sample components and the two phases results in differential migration rates, effectively separating the mixture into its individual constituents. HPLC offers robust separation capabilities for a wide range of analytes, while UPLC enhances resolution and speed by utilizing smaller particle sizes and higher pressures. LC/MS combines the power... + More

High-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (UPLC), and liquid chromatography-mass spectrometry (LC/MS) systems are essential tools in modern analytical laboratories. These sophisticated instruments are used to separate, identify, and quantify the components within complex mixtures. They work by leveraging the principles of chromatography, where a sample is dissolved in a mobile phase and passed through a stationary phase (typically a packed column). The interaction between the sample components and the two phases results in differential migration rates, effectively separating the mixture into its individual constituents. HPLC offers robust separation capabilities for a wide range of analytes, while UPLC enhances resolution and speed by utilizing smaller particle sizes and higher pressures. LC/MS combines the power of liquid chromatography with the high sensitivity and selectivity of mass spectrometry, enabling both qualitative and quantitative analysis of even trace-level compounds. These techniques support diverse workflows across various scientific disciplines. They play a vital role in pharmaceutical research and development, environmental analysis, food safety testing, and clinical diagnostics. Common applications include drug discovery and development, where HPLC, UPLC, and LC/MS are used to analyze drug purity, stability, and pharmacokinetics. In environmental science, these instruments are employed to monitor pollutants in water, soil, and air. Food scientists utilize them to detect contaminants and adulterants in food products. Clinical laboratories rely on these technologies for therapeutic drug monitoring, toxicology screening, and disease biomarker discovery. These instruments often integrate with other analytical techniques like spectroscopy for enhanced characterization of samples. They are also essential components of more complex workflows involving sample preparation, data acquisition, and data analysis. Leading manufacturers like Thermo Fisher Scientific, Agilent Technologies, Waters Corporation, Shimadzu, and AB Sciex offer a wide range of HPLC, UPLC, and LC/MS systems, each with specific features and capabilities. Examples include the Thermo Fisher Vanquish UHPLC, the Agilent 1290 Infinity II LC, and the Waters Acquity UPLC. Choosing the right system depends on the specific application and analytical requirements. At American Laboratory Trading (ALT), we offer a comprehensive selection of refurbished HPLC, UPLC, and LC/MS systems from these top brands. Our experienced in-house engineering team meticulously refurbishes, tests, and services each instrument to meet original equipment manufacturer (OEM) specifications. Every instrument comes with a 90-day warranty, upgradeable to one year, and lifetime support. We understand the critical nature of uptime in your laboratory, which is why we're dedicated to providing reliable, ongoing support for all your equipment needs. Our commitment to quality, combined with our competitive pricing and price match guarantee, ensures you receive the best value for your investment. As North America's largest provider of premium refurbished lab equipment, we offer a vast inventory of over 6,000 instruments, enabling you to find the perfect fit for your laboratory. With our white glove service and flexible payment options through ALT Capital, acquiring and integrating your new equipment is seamless and stress-free, allowing you to focus on your important research. - Less