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Tips and Tricks: 6 Steps to Clean or Replace HPLC Solvent Inlet Filters

August 17, 2015

In the realm of high-performance liquid chromatography (HPLC), myriad challenges can arise, from erratic system pressures to obstructed lines and columns. If you observe high back pressure, follow the troubleshooting tips below.

Here are some practical guidelines for HPLC maintenance:

  • Remove solvent inlet filters periodically for inspection
  • For glass filters, consider soaking them in concentrated nitric acid (35%) for one hour
  • For stainless steel filters, consider sonicating for one hour
  • Thoroughly flush with filtered solvent to prevent potential column damage
  • Reinstall solvent inlet filters promptly after maintenance
  • Always maintain any inventory of spare solvent inlet filters
  • By adhering to these protocols, you can proactively mitigate potential issues and optimize the performance of your HPLC instrument.

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